DEHP Correction

A content of resin monomers and degradation prod-ucts[abstract]. EB, Lee-Chou L. In vitro elution of leachable components from dental sealants. The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Profound effects of the weak environmental estrogen-like chemical bisphe-nol A on the growth of the mammary gland of Noble rats. Interference with microtubules and induction of micronuclei in vitro by various bisphenols.gens: effects on cholesterol lowering and bone in the ovariectomized rat. hepatic expression of the estrogen-regulated messenger -RNA stabilizing factor by estrogenic and antiestrogenic nonsteroidal xenobiotics. Relative binding affinity-serum modified access (RBA-SMA(assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy reported an analysis conducted as part of the U.S. Environmental Protection Agency (EPA) Cumulative Exposure Project (CEP). The EPA modeled air concentrations of chemicals listed in the Clean Air Act as hazardous air pollutants (HAPs) in over 60,000 census tracts and compared those concentrations to health benchmarks. The Phthalate Esters Panel of the Chemical Manufacturers Association has become aware of an error in the background concentration value used for bis(2-ethylhexyl) phthalate (DEHP), with the result that modeled air concentrations for DEHP-and thus the potential health hazard-were greatly exaggerated. Woodruff et al. (1) reported, "Eight pollutants ... [including DEHP] had mod-eled concentrations exceeding the benchmark concentrations for cancer in 1 00% of the census tracts. For each of these HAPs, the background concentration alone ... exceeded the benchmark concentration for cancer, as shown in Table 2." Their Table 2 (1) shows that the background concentration used for DEHP was 1.6 pg/m3. That value was taken from Howard (2) who reported "mean remote ocean air concen-trations" for DEHP of 0.07-0.17 ppb, citing Atlas and Giam (3). However, Atlas and Giam (3) actually reported remote DEHP air concentrations to be 0.32-2.68 ng/m3, with a mean of 1.4 ng/m3 a value more than 1,000 times less than the background value used for the CEP analysis. The panel has alerted the EPA to this error, and the EPA accordingly has corrected the CEP modeling report (4). TIable 2 of Woodruff et al. (1) shows that if the erroneous background value of 1.6 pg/m3 is disregarded, the CEP model predicts DEHP air concentrations to exceed the health benchmark of 0.25 pg/m3 in only 18 census tracts. Even this estimate probably exaggerates …